The immune system composes a variety of cells with different functions. One of the most important cell types involved in the innate immune system is the macrophages. Macrophages have a wide range of functions: from bacteria-killing to wound healing properties. Classically, the macrophages can be classified to M1 and M2 phenotypes. The M1 phenotype is the classical activated macrophages that related to defensive reaction. The M2 phenotype is well-known as the alternatively activated macrophages, which takes function during wound healing and anti-inflammatory phase.
We are tying to understand the mechanism of macrophages activation and inflammatory cytokines release, especially the inflammasome activation and IL-1 family cytokines.