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![[Article] Trojan Horse Effect of Biologically Aged Microplastics-An Intracellular Carrier of LPS for Licensing Noncanonical Inflammasome Activation](https://static.wixstatic.com/media/da786b_2a602cfba6e74c3aaedfd40fc78b9bcc~mv2.jpeg/v1/fill/w_333,h_250,fp_0.50_0.50,q_30,blur_30,enc_avif,quality_auto/da786b_2a602cfba6e74c3aaedfd40fc78b9bcc~mv2.webp)
![[Article] Trojan Horse Effect of Biologically Aged Microplastics-An Intracellular Carrier of LPS for Licensing Noncanonical Inflammasome Activation](https://static.wixstatic.com/media/da786b_2a602cfba6e74c3aaedfd40fc78b9bcc~mv2.jpeg/v1/fill/w_453,h_340,fp_0.50_0.50,q_90,enc_avif,quality_auto/da786b_2a602cfba6e74c3aaedfd40fc78b9bcc~mv2.webp)
[Article] Trojan Horse Effect of Biologically Aged Microplastics-An Intracellular Carrier of LPS for Licensing Noncanonical Inflammasome Activation
We have published an article in Environmental Science & Technology: Trojan Horse Effect of Biologically Aged Microplastics-An Intracellular Carrier of LPS for Licensing Noncanonical Inflammasome Activation. Its doi is https://pubs.acs.org/doi/10.1021/acs.est.5c12882 Abstract Microplastics (MPs), due to their poor degradability, can accumulate in the body following ingestion. Most studies evaluating MP safety use pristine particles or those aged for a short period, thus overlo
Feb 91 min read
![[Article] Amino Acid Residue-Driven Nanoparticle Targeting of Protein Cavities: Surface Chemistry Dictates Binding Specificity beyond Size Complementarity](https://static.wixstatic.com/media/da786b_60bd02d45c5341de8294bda04ced11b8~mv2.jpg/v1/fill/w_333,h_250,fp_0.50_0.50,q_30,blur_30,enc_avif,quality_auto/da786b_60bd02d45c5341de8294bda04ced11b8~mv2.webp)
![[Article] Amino Acid Residue-Driven Nanoparticle Targeting of Protein Cavities: Surface Chemistry Dictates Binding Specificity beyond Size Complementarity](https://static.wixstatic.com/media/da786b_60bd02d45c5341de8294bda04ced11b8~mv2.jpg/v1/fill/w_453,h_340,fp_0.50_0.50,q_90,enc_avif,quality_auto/da786b_60bd02d45c5341de8294bda04ced11b8~mv2.webp)
[Article] Amino Acid Residue-Driven Nanoparticle Targeting of Protein Cavities: Surface Chemistry Dictates Binding Specificity beyond Size Complementarity
We have published an article in Journal of the American Chemical Society : Amino Acid Residue-Driven Nanoparticle Targeting of Protein Cavities: Surface Chemistry Dictates Binding Specificity beyond Size Complementarity. Its doi is https://pubs.acs.org/doi/full/10.1021/jacs.5c15860 Abstract Cavities at protein-protein interaction interfaces are considered “undruggable” because their shallow or large geometries hinder stable binding by small molecules. Overcoming this limitat
Feb 92 min read
![[News] 2025人类黏膜免疫国际大会在深召开](https://static.wixstatic.com/media/da786b_4408704735664590a8311eb1022a776a~mv2.png/v1/fill/w_333,h_250,fp_0.50_0.50,q_35,blur_30,enc_avif,quality_auto/da786b_4408704735664590a8311eb1022a776a~mv2.webp)
![[News] 2025人类黏膜免疫国际大会在深召开](https://static.wixstatic.com/media/da786b_4408704735664590a8311eb1022a776a~mv2.png/v1/fill/w_453,h_340,fp_0.50_0.50,q_95,enc_avif,quality_auto/da786b_4408704735664590a8311eb1022a776a~mv2.webp)
[News] 2025人类黏膜免疫国际大会在深召开
2025年7月4日至6日,由中国科学院深圳先进技术研究院(以下简称“深圳先进院”)主办的2025人类黏膜免疫国际大会(Human Mucosal Immunization 2025: Bacterial Infections and Beyond Challenges in Defining Correlates of Protection)在深圳举行。本次大会汇聚了来自中国、意大利、瑞典、巴西、韩国、英国等多个国家的知名免疫学家、微生物学家以及来自包括康希诺、复诺健等国际知名生物医药公司在内的疫苗研发项目负责人,围绕黏膜免疫保护机制、细菌感染防控策略及疫苗研发等核心议题展开深度研讨,旨在推动全球黏膜免疫领域的跨学科合作与技术创新。 来自英国帝国理工大学、瑞典卡罗林斯卡医学院、巴西布坦坦研究所、韩国首尔国立大学、香港大学等多个国际知名高校和研究所的资深学者就相关主题进行了细致深刻的交流与探讨,内容涵盖了黏膜疫苗临床应用的发展、粘膜免疫的器官和病原体依赖性特异性、黏膜疫苗的接种策略及以个体免疫特征为基础,制定个性化防护策略等多个议题。同时与参会的众
Feb 91 min read
![[News] 深圳先进院与意大利锡耶纳生物技术园基金会签署合作协议,全面启动疫苗领域战略合作](https://static.wixstatic.com/media/da786b_5598f15990a641a0a7c4bcad1f022921~mv2.jpg/v1/fill/w_333,h_250,fp_0.50_0.50,q_30,blur_30,enc_avif,quality_auto/da786b_5598f15990a641a0a7c4bcad1f022921~mv2.webp)
![[News] 深圳先进院与意大利锡耶纳生物技术园基金会签署合作协议,全面启动疫苗领域战略合作](https://static.wixstatic.com/media/da786b_5598f15990a641a0a7c4bcad1f022921~mv2.jpg/v1/fill/w_453,h_340,fp_0.50_0.50,q_90,enc_avif,quality_auto/da786b_5598f15990a641a0a7c4bcad1f022921~mv2.webp)
[News] 深圳先进院与意大利锡耶纳生物技术园基金会签署合作协议,全面启动疫苗领域战略合作
2025年7月7日,中国科学院深圳先进技术研究院(以下简称“深圳先进院”)与意大利锡耶纳生物技术园基金会(Fondazione Biotecnopolo di Siena,以下简称“FBS”)正式签署机构间合作协议,标志着双方在黏膜疫苗佐剂领域的战略合作全面升级。合作协议由FBS总干事Gianluca Polifrone与深圳先进院副院长梁栋代表双方签署,意大利驻广州总领事Valerio De Parolis、FBS科学总监Rino Rappuoli、中国科学院国际合作局欧洲处处长宁博伦等出席见证。 根据此次协议,双方将围绕科研合作平台建设、技术开发与转化、人才交流与国际网络建设三大方向持续深化合作。FBS将充分发挥其在意大利高校、科研机构及相关企业中的资源优势,与深圳先进院共同推动黏膜疫苗佐剂领域的关键技术攻关与平台搭建;同时,依托FBS在疫苗注册、临床试验及产业化方面的丰富经验,支持中方加快候选佐剂产品的临床前开发;此外,双方还将共同推动中意及中欧间在生物医药领域的人才流动、项目对接与国际合作网络的构建,探索可持续的协同创新机制。...
Feb 91 min read
![[News]第二届纳米生物学国际研讨会在深召开](https://static.wixstatic.com/media/da786b_b96777fd867747f5b1c21c5857bac3d1~mv2.jpg/v1/fill/w_333,h_250,fp_0.50_0.50,q_30,blur_30,enc_avif,quality_auto/da786b_b96777fd867747f5b1c21c5857bac3d1~mv2.webp)
![[News]第二届纳米生物学国际研讨会在深召开](https://static.wixstatic.com/media/da786b_b96777fd867747f5b1c21c5857bac3d1~mv2.jpg/v1/fill/w_453,h_340,fp_0.50_0.50,q_90,enc_avif,quality_auto/da786b_b96777fd867747f5b1c21c5857bac3d1~mv2.webp)
[News]第二届纳米生物学国际研讨会在深召开
11月1日至3日,由中国科学院深圳先进技术研究院(简称“深圳先进院”)主办,中国毒理学会纳米毒理学专业委员会协办的第二届纳米生物学国际研讨会(2nd International Symposium on Nanobiology)在深圳市举行。来自英国、西班牙、奥地利、意大利...
Nov 5, 20242 min read
![[News]SIAT and Italian Partners Launch the China-Italy Joint Laboratory of Pharmacobiotechnology for Medical Immunomodulation](https://static.wixstatic.com/media/da786b_8e6c1273d34f484298f2d743422aa9bf~mv2.png/v1/fill/w_333,h_250,fp_0.50_0.50,q_35,blur_30,enc_avif,quality_auto/da786b_8e6c1273d34f484298f2d743422aa9bf~mv2.webp)
![[News]SIAT and Italian Partners Launch the China-Italy Joint Laboratory of Pharmacobiotechnology for Medical Immunomodulation](https://static.wixstatic.com/media/da786b_8e6c1273d34f484298f2d743422aa9bf~mv2.png/v1/fill/w_453,h_340,fp_0.50_0.50,q_95,enc_avif,quality_auto/da786b_8e6c1273d34f484298f2d743422aa9bf~mv2.webp)
[News]SIAT and Italian Partners Launch the China-Italy Joint Laboratory of Pharmacobiotechnology for Medical Immunomodulation
On November 3rd, the Shenzhen Institutes of Advanced Technology (SIAT) of the Chinese Academy of Sciences (CAS) held an inauguration...
Nov 5, 20241 min read
![[News] International academic exchange activities of the Autonomous University of Barcelona](https://static.wixstatic.com/media/da786b_01d44df90b4a41d1896cbf37e7f93034~mv2.jpg/v1/fill/w_333,h_250,fp_0.50_0.50,q_30,blur_30,enc_avif,quality_auto/da786b_01d44df90b4a41d1896cbf37e7f93034~mv2.webp)
![[News] International academic exchange activities of the Autonomous University of Barcelona](https://static.wixstatic.com/media/da786b_01d44df90b4a41d1896cbf37e7f93034~mv2.jpg/v1/fill/w_453,h_340,fp_0.50_0.50,q_90,enc_avif,quality_auto/da786b_01d44df90b4a41d1896cbf37e7f93034~mv2.webp)
[News] International academic exchange activities of the Autonomous University of Barcelona
From Sep. 19th to 21st, Prof. Li and team members conducted the international academic exchange at the Catalan Institute of Nanoscience...
Oct 4, 20241 min read
![[Article]Nano-assemblies overcome cancer multidrug resistance for effectively synergistic chemo-immuno-oncotherapy](https://static.wixstatic.com/media/da786b_075198fadb284750bc45d7edc911978a~mv2.png/v1/fill/w_333,h_250,fp_0.50_0.50,q_35,blur_30,enc_avif,quality_auto/da786b_075198fadb284750bc45d7edc911978a~mv2.webp)
![[Article]Nano-assemblies overcome cancer multidrug resistance for effectively synergistic chemo-immuno-oncotherapy](https://static.wixstatic.com/media/da786b_075198fadb284750bc45d7edc911978a~mv2.png/v1/fill/w_453,h_340,fp_0.50_0.50,q_95,enc_avif,quality_auto/da786b_075198fadb284750bc45d7edc911978a~mv2.webp)
[Article]Nano-assemblies overcome cancer multidrug resistance for effectively synergistic chemo-immuno-oncotherapy
We have published an article in Chemical Engineering Journal: Nano-assemblies overcome cancer multidrug resistance for effectively...
Jun 24, 20241 min read
![[Article]Strengthening the Combinational Immunotherapy from Modulating the Tumor Inflammatory Environment via Hypoxia-Responsive Nanogels](https://static.wixstatic.com/media/da786b_1db0c19f63ba43178c18ee56db8d4af0~mv2.png/v1/fill/w_333,h_250,fp_0.50_0.50,q_35,blur_30,enc_avif,quality_auto/da786b_1db0c19f63ba43178c18ee56db8d4af0~mv2.webp)
![[Article]Strengthening the Combinational Immunotherapy from Modulating the Tumor Inflammatory Environment via Hypoxia-Responsive Nanogels](https://static.wixstatic.com/media/da786b_1db0c19f63ba43178c18ee56db8d4af0~mv2.png/v1/fill/w_453,h_340,fp_0.50_0.50,q_95,enc_avif,quality_auto/da786b_1db0c19f63ba43178c18ee56db8d4af0~mv2.webp)
[Article]Strengthening the Combinational Immunotherapy from Modulating the Tumor Inflammatory Environment via Hypoxia-Responsive Nanogels
We have published an article in Adv Healthc Mater: Strengthening the Combinational Immunotherapy from Modulating the Tumor Inflammatory...
Dec 26, 20231 min read
![[News]The 5th Annual Meeting of Chinese American Society of Nanomedicine and Nanobiotechnology](https://static.wixstatic.com/media/da786b_3a7f43f217064b85bf7c8bfb241c1c56~mv2.png/v1/fill/w_333,h_250,fp_0.50_0.50,q_35,blur_30,enc_avif,quality_auto/da786b_3a7f43f217064b85bf7c8bfb241c1c56~mv2.webp)
![[News]The 5th Annual Meeting of Chinese American Society of Nanomedicine and Nanobiotechnology](https://static.wixstatic.com/media/da786b_3a7f43f217064b85bf7c8bfb241c1c56~mv2.png/v1/fill/w_453,h_340,fp_0.50_0.50,q_95,enc_avif,quality_auto/da786b_3a7f43f217064b85bf7c8bfb241c1c56~mv2.webp)
[News]The 5th Annual Meeting of Chinese American Society of Nanomedicine and Nanobiotechnology
From December 8 to 10, The 5th Annual Meeting of Chinese American Society of Nanomedicine and Nanobiotechnology was held in Guangzhou....
Dec 25, 20231 min read
![[News] Professor Iseult Lynch was invited to give an academic lecture to our research group.](https://static.wixstatic.com/media/da786b_125b749d7b02410581f4b07b39f94679~mv2.jpg/v1/fill/w_333,h_250,fp_0.50_0.50,q_30,blur_30,enc_avif,quality_auto/da786b_125b749d7b02410581f4b07b39f94679~mv2.webp)
![[News] Professor Iseult Lynch was invited to give an academic lecture to our research group.](https://static.wixstatic.com/media/da786b_125b749d7b02410581f4b07b39f94679~mv2.jpg/v1/fill/w_453,h_340,fp_0.50_0.50,q_90,enc_avif,quality_auto/da786b_125b749d7b02410581f4b07b39f94679~mv2.webp)
[News] Professor Iseult Lynch was invited to give an academic lecture to our research group.
Prof. Iseult Lynch, School of Geography, Earth and Environmental Sciences, University of Birmingham, is a Fellow of the Royal Society of...
Dec 25, 20231 min read
![[Article]Tailoring multivalent nanomedicines for monkeypox.](https://static.wixstatic.com/media/da786b_49deadd159a14f3fa88eb6c23612012f~mv2.jpg/v1/fill/w_333,h_250,fp_0.50_0.50,q_30,blur_30,enc_avif,quality_auto/da786b_49deadd159a14f3fa88eb6c23612012f~mv2.webp)
![[Article]Tailoring multivalent nanomedicines for monkeypox.](https://static.wixstatic.com/media/da786b_49deadd159a14f3fa88eb6c23612012f~mv2.jpg/v1/fill/w_453,h_340,fp_0.50_0.50,q_90,enc_avif,quality_auto/da786b_49deadd159a14f3fa88eb6c23612012f~mv2.webp)
[Article]Tailoring multivalent nanomedicines for monkeypox.
The article Tailoring multivalent nanomedicines for monkeypox. has been published in Nano Today! Its doi is doi.org/10.1016/j.nantod.20...
Dec 25, 20231 min read
![[News] Won the second prize of Life Science Innovation and Entrepreneurship Challenge Competition](https://static.wixstatic.com/media/da786b_020351fde7f246459275c79282139c31~mv2.jpg/v1/fill/w_333,h_250,fp_0.50_0.50,q_30,blur_30,enc_avif,quality_auto/da786b_020351fde7f246459275c79282139c31~mv2.webp)
![[News] Won the second prize of Life Science Innovation and Entrepreneurship Challenge Competition](https://static.wixstatic.com/media/da786b_020351fde7f246459275c79282139c31~mv2.jpg/v1/fill/w_453,h_340,fp_0.50_0.50,q_90,enc_avif,quality_auto/da786b_020351fde7f246459275c79282139c31~mv2.webp)
[News] Won the second prize of Life Science Innovation and Entrepreneurship Challenge Competition
The Life Science Innovation and Entrepreneurship Challenge Competition(South China ), sponsored by Novizan and Shengjing and supported by...
Dec 19, 20231 min read
![[News] The 5th International Conference on Nanomedicine](https://static.wixstatic.com/media/da786b_e1ffdb8f6a67472e891a50b3aef3acf9~mv2.jpg/v1/fill/w_333,h_250,fp_0.50_0.50,q_30,blur_30,enc_avif,quality_auto/da786b_e1ffdb8f6a67472e891a50b3aef3acf9~mv2.webp)
![[News] The 5th International Conference on Nanomedicine](https://static.wixstatic.com/media/da786b_e1ffdb8f6a67472e891a50b3aef3acf9~mv2.jpg/v1/fill/w_453,h_340,fp_0.50_0.50,q_90,enc_avif,quality_auto/da786b_e1ffdb8f6a67472e891a50b3aef3acf9~mv2.webp)
[News] The 5th International Conference on Nanomedicine
From November 5 to 7, the 5th International Nanomedicine Conference was held in Guangzhou, with 21 academicians from China, Sweden,...
Nov 20, 20231 min read
![[News]The first International Symposium on Nanobiology of SIAT](https://static.wixstatic.com/media/da786b_3884a2541988473bb9ce2def01bb66dd~mv2.jpg/v1/fill/w_333,h_250,fp_0.50_0.50,q_30,blur_30,enc_avif,quality_auto/da786b_3884a2541988473bb9ce2def01bb66dd~mv2.webp)
![[News]The first International Symposium on Nanobiology of SIAT](https://static.wixstatic.com/media/da786b_3884a2541988473bb9ce2def01bb66dd~mv2.jpg/v1/fill/w_453,h_340,fp_0.50_0.50,q_90,enc_avif,quality_auto/da786b_3884a2541988473bb9ce2def01bb66dd~mv2.webp)
[News]The first International Symposium on Nanobiology of SIAT
On August 30, the first SIAT International Symposium on Nanobiology, organized by the Institute of Biomedicine and Biotechnology (IBB),...
Oct 7, 20231 min read
![[News]Kick-off meeting of China-Italy project](https://static.wixstatic.com/media/da786b_b2b2039a522d48f9bfc6b01b5f1741f5~mv2.png/v1/fill/w_333,h_250,fp_0.50_0.50,q_35,blur_30,enc_avif,quality_auto/da786b_b2b2039a522d48f9bfc6b01b5f1741f5~mv2.webp)
![[News]Kick-off meeting of China-Italy project](https://static.wixstatic.com/media/da786b_b2b2039a522d48f9bfc6b01b5f1741f5~mv2.png/v1/fill/w_453,h_340,fp_0.50_0.50,q_95,enc_avif,quality_auto/da786b_b2b2039a522d48f9bfc6b01b5f1741f5~mv2.webp)
[News]Kick-off meeting of China-Italy project
Feb. 10th, the kick-off meeting of China-Italy project was held in Shenzhen Blood Center. The project, which focuses on "Development of...
Feb 11, 20231 min read


Start a New Journey of Vaccine Research in China——Prof. Aldo Tagliabue
View full article: https://english.siat.ac.cn/News2017/SN2017/202301/t20230109_326142.html
Jan 10, 20231 min read
![[News]Congratulations to Prof. Boraschi on winning the Chinese Government Friendship Award!](https://static.wixstatic.com/media/da786b_4f5ffa439bf846b8a227282ebbdf98b7~mv2.jpg/v1/fill/w_333,h_250,fp_0.50_0.50,q_30,blur_30,enc_avif,quality_auto/da786b_4f5ffa439bf846b8a227282ebbdf98b7~mv2.webp)
![[News]Congratulations to Prof. Boraschi on winning the Chinese Government Friendship Award!](https://static.wixstatic.com/media/da786b_4f5ffa439bf846b8a227282ebbdf98b7~mv2.jpg/v1/fill/w_453,h_340,fp_0.50_0.50,q_90,enc_avif,quality_auto/da786b_4f5ffa439bf846b8a227282ebbdf98b7~mv2.webp)
[News]Congratulations to Prof. Boraschi on winning the Chinese Government Friendship Award!
On September 30, 2022, Premier Li Keqiang of the State Council met with foreign experts who have won the 2022 Chinese Government...
Oct 1, 20221 min read
![[Article]Anti-Coronavirus Nanomaterial with Broad Spectrum,High Efficacy published on Nat. Nanotech.](https://static.wixstatic.com/media/da786b_6ac5134e3ec24659840b942e56e41811~mv2.jpg/v1/fill/w_333,h_250,fp_0.50_0.50,q_30,blur_30,enc_avif,quality_auto/da786b_6ac5134e3ec24659840b942e56e41811~mv2.webp)
![[Article]Anti-Coronavirus Nanomaterial with Broad Spectrum,High Efficacy published on Nat. Nanotech.](https://static.wixstatic.com/media/da786b_6ac5134e3ec24659840b942e56e41811~mv2.jpg/v1/fill/w_453,h_340,fp_0.50_0.50,q_90,enc_avif,quality_auto/da786b_6ac5134e3ec24659840b942e56e41811~mv2.webp)
[Article]Anti-Coronavirus Nanomaterial with Broad Spectrum,High Efficacy published on Nat. Nanotech.
A joint research team led by Dr. LI Yang from the Shenzhen Institute of Advanced Technology (SIAT) of the Chinese Academy of Sciences...
Aug 22, 20223 min read
![[News]“纳米磷疗”新策略](https://static.wixstatic.com/media/da786b_dfe66b5169f140ae916a4747237e4f0e~mv2.png/v1/fill/w_333,h_250,fp_0.50_0.50,q_35,blur_30,enc_avif,quality_auto/da786b_dfe66b5169f140ae916a4747237e4f0e~mv2.webp)
![[News]“纳米磷疗”新策略](https://static.wixstatic.com/media/da786b_dfe66b5169f140ae916a4747237e4f0e~mv2.png/v1/fill/w_453,h_340,fp_0.50_0.50,q_95,enc_avif,quality_auto/da786b_dfe66b5169f140ae916a4747237e4f0e~mv2.webp)
Aug 11, 20220 min read
The Li Lab: Immunity and Nano
What We Do

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