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Guofang Zhang（张国芳）

Associate Professor

email: gf.zhang@siat.ac.cn

Dr. Guofang Zhang, associate professor in the Laboratory of Immunology and Nanomedicine of Shenzhen Institute of Advanced Technology (SIAT), Chinese Academy of Sciences (CAS). She received a PhD degree majored in cell biology, which mainly focused on the protein-protein and protein-nucleic acid interactions to explore the mechanisms of cell signal transduction.

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Her postdoctoral training was on nano-immune interactions at SIAT-CAS. Her currently study mainly focuses in two directions: 1) molecular mechanisms of nanoparticles on cyto-/immune-toxicity; 2) the functions and molecular mechanisms of antiviral nanomaterials. She is trying to combine the molecular biological techniques with the nanotechnology for a smart nanomaterial development and a deep understanding of their potential biological/immunological functions.

Dr. Zhang has published more than 10 papers, including 7 first authored publications at Nature Nanotechnology, Environmental Science: Nano, ACS Applied Materials & Interfaces, WIREs Nanomedicine & Nanobiotechnology, etc.

Published papers:

  1. Guofang Zhang, Yalin Cong, Feng-Liang Liu, Jiufeng Sun, Jiantian Zhang, Guoli Cao, Lingqiang Zhou, Wenjie Yang, Qingle Song, Fangjun Wang, Ke Liu, Jing Qu, Jing Wang, Min He, Shun Feng, Didar Baimanov, Wei Xu, Rong-Hua Luo, Xin-Yan Long, Shumin Liao, Yunping Fan, Yufeng Li, Bai Li, Ximing Shao, Guocheng Wang, Lijing Fang, Huaiyu Wang, Xue-Feng Yu, Yanzhong Chang, Yuliang Zhao, Liang Li, Peng Yu, Yong-Tang Zheng*, Diana Boraschi, Hongchang Li*, Chunying Chen*, Liming Wang*, Yang Li*. A nanomaterial targeting the spike protein captures SARS-CoV-2 variants and promotes viral elimination. Nature Nanotechnology, 2022, 17, 993–1003, doi: 10.1038/s41565-022-01177-2.

  2. Guofang Zhang, Guoli Cao, Rong-Hua Luo, Qingle Song, Yanqiao Zeng, Ke Liu, Jing Qu, Xian Lin, Feng-Liang Liu, Guocheng Wang, Hongchang Li, Liang Li, Yong-Tang Zheng, Diana Boraschi, Lidong Wu, Yan-Zhong Chang and Yang Li. Microplastics interact with SARS-CoV-2 and facilitate host cell infection. Environmental Science: Nano, 2022, 9, 2653-2664. doi: 10.1039/D2EN00019A.

  3. Guofang Zhang, Wenhe Luo, Wenjie Yang, Su Li, Dongjie Li, Yanqiao Zeng, Yang Li*. The Importance of IL-1 Family Cytokines in Nanoimmunosafety and Nanotoxicology. WIREs Nanomedicine & Nanobiotechnology, 2022, 14(6):e1850. doi: 10.1002/wnan.1850.

  4. Qingle Song, Guofang Zhang, Bo Wang; Guoli Cao; Dongjie Li; Yu Wang; Yuqian Zhang; Jin Geng; Hongchang Li; Yang Li*; Reinforcing the Combinational Immuno-Oncotherapy of Switching “Cold” Tumor to “Hot” by Responsive Penetrating Nanogels, ACS Applied Materials & Interfaces, 2021,13(31): 36824-36838. doi: 10.1021/acsami.1c08201 (co-first author)

  5. Yuqian Zhang; Guofang Zhang; Guocheng Wang; Lidong Wu; Nancy A. Monteiro-Riviere; Yang Li*. The Synergistic Strategies for the Immuno-Oncotherapy with Photothermal Nanoagents. WIREs Nanomedicine & Nanobiotechnology. 2021, 13(5):e1717. doi: 10.1002/wnan.1717. (co-first author)

 

Patents:

1. 李洋; 王黎明; 张国芳; 二维纳米材料在抑制冠状病毒的应用, 2021-2-10, 中国, 202110183434X. 
2. 李洋; 王黎明; 张国芳; 二维纳米材料在抑制冠状病毒的应用, 2021-2-22, 中国, PCT/CN2021/077226.
3. 李洋; 张国芳; 金纳米材料在抑制冠状病毒中的应用, 2021-2-10, 中国, 2021101839019. 
4. 崔素娟; 赵红桃; 张国芳; 一种转录抑制结构域、其编码基因及其应用, 2018-5-25, 中国, 2018105121706.

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